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UMR-S 974 – Research Center in Myology



INSERM and Sorbonne University
AIM partenaire

Scientific partner

Created on January 1, 2014, the Research Center in Myology, is a multidisciplinary research center on muscle and its pathologies.
The objective of UMRS 974 is to develop innovative approaches to cell, gene or pharmacogenetic therapies, based on an understanding of the molecular pathophysiology of a given disease, and therefore adapted to it.

Research teams

  • Team 1: myomatrix & myonucleus related diseases: genetics & pathophysiology  (Gisèle Bonne)
  • Team 2 : muscle cell organization & therapy of dominant centronuclear myopathy  (Marc Bitoun)
  • Team 3: cell and molecular orchestration in muscle regeneration, ageing and diseases  (Capucine Trollet)
  • Team 4 : repeat expansion & myotonic dystrophy (Denis Furling)
  • Team 7: myasthenia gravis: etiology, physiopathology & therapeutic approaches  (Rozen Le Panse)
  • Team 8: inflammatory muscle & innovative therapies  (Olivier Benveniste)*
    o Group 5: gene therapy for dmd and pathophysiology of skeletal muscle (France Piétri-Rouxel)
    o Group 6:  biotherapies & pathophysiology of neuromuscular disorders (Maria-Grazia Biferi)
  • Team 9: signaling pathways & striated muscles  (Fabien Le Grand)
  • Team 10:  neuromuscular connectivity in health & diseases (Bertrand Fontaine)


  • Biomarker patent for DMD
  • Lorain S and Garcia L.Nucleic acid molecules and methods for exchanging exon by double-transplicing. Patent 9303078. Association Institute of Myology, CNRS, Inserm, Sorbonne University. Filed in 2010, delivered in 2016.
  • F. Piétri-Rouxel and V. François. Effective gene therapy tools for the jump of the exon 53 of the dystrophin-Patent application deposit 2015 1562036 / Ref G143-B-45963 EN; 2016. International deposit PCT: fr2016: 053312
  • Lorain S, Voit T, M Wood & McClorey G. Combined therapy for Duchenne muscular dystrophy. No. 15 305890.4. Association Institute of Myology, Inserm, Sorbonne University, CNRS. Filed in 2015



Research Center in Myology
Faculté de Médecine Sorbonne université
Site Pitié Salpêtrière
Bureau 213 – 2e étage
105 boulevard de l’Hôpital – 75013 Paris

Florence COTTU
Phone : +33 140 77 81 47


Partner website
Fondation Oswaldo Cruz (Fiocruz)

Doctoral Schools
ED 515 – Complexité du Vivant
ED 394 – Physiologie, physiopathologie et thérapeutique

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