Two supervisor body :
INSERM and Sorbonne Université
Two scientific interacting orientations are identified: Research in Oncology and Haematology; and Research in Metabolism and Inflammation and Tissue Repair. They include several aspects of translational research: Fundamental; Preclinical; Pathophysiological and Aspects more specifically clinical.
The Research Centre developed collective facilities (such as L2, L3 laboratories) but is also implicated in technologic networks (such as Mass spectrometry, lipidomic and proteomic; Cell and tissue imagery, flow cytometry ; and functional exploration of small animals).
Oncology and Hematology
Microsatellite instability and cancer
TGF- β signaling in cellular plasticity and cancer
Cancer biology and therapeutics
Our research is centered on the following axes :
- Tumor cell plasticity, in particular epithelial-mesenchymal transition (EMT) and stem cell phenotypes. The relationships between invasion, chemoresistance and recruitment of immune cells. Role of CCN proteins and alarmins.
- The vascular tumor environment. Relationship between cancer and thrombosis. Vascular mimicry and circulating tumour cells.
- Development of new drugs or drug combinations. Identification of prognostic or predictive biomarkers.
Hematopoietic and leukemic development: diseases and cell therapy
The first group is dedicated to myeloid malignancies. It studies the development of adult and children acute myeloid leukemia in two contexts : the context of age-related clonal hematopoiesis, and the context of genetic predisposing syndromes such as congenital neutropenia. Ongoing studies are focused on the clonal hierarchy and its relationship with the crosstalk between leukemic cells and their microenvironment.
The second group is dedicated to normal and pathologic erythropoiesis on one hand, and to the in vitro production of hematopoietic stem and progenitor cells for the purpose of transfusion and cell therapy on the other hand.
The projects of the two groups share the need to understand the mechanisms that
Govern cell fate and the commitment of hematopoietic stem and progenitor cell towards the various blood lineages.
Pr François DELHOMMEAU
Contact : email@example.com
Graft-versus-host reactions after allogenic hematopoietic stem cell transplantation
Metabolism and Inflammation axis
Metabolic diseases and age-related joint pathologies
Our team has been interested for several years in the objective to discover innovative treatments and biomarkers in osteoarthritis (OA). We have developed several tools, from cell cultures to human cohort, from preclinical murine models to joint tissue analysis. Our projects are focused on the relations between OA and metabolic diseases:
- Role of innate immunity in OA
- Role of chondrocyte differentiation on bone angiogenesis
- Role of the cholinergic system in OA
- Role of adipose tissues in OA
Cystic fibrosis physiopathology and phenogenomics
Immune system and neuro-inflammation
Dr Guillaume DOROTHEE
Contact : firstname.lastname@example.org
Lipodystrophies, metabolic and hormonal adaptations, and aging
Lipodystrophic syndromes are characterized by a defect in adipose tissue distribution and function, with potential metabolic, cardiovascular, and reproductive consequences. Thanks to in vivo (animal models, patient cohorts) and in vitro models we aim to: (i) understand the clinical and pathophysiological links between lipodystrophies, insulin resistance, adipose tissue aging, cardio-metabolic complications, and reproductive disorders; (ii) identify new therapeutic tools.
Neuroendocrine mechanisms of longevity and age-related diseases
Dr Martin HOLZENBERGER
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Metabolic and biliary fibro-inflammatory diseases of the liver
IGF system and foetal and postnatal growth
Our objectives are to improve the early detection of fetal growth abnormalities and childhood tumors and to understand the regulation of growth and metabolism, in order to propose new treatment strategies aimed at improving fetal growth, metabolism and tumor prognosis.
Microbiota, gut and inflammation
+(33) 1 49 28 46 87
+(33) 1 49 28 46 90
Faculté de Médecine Sorbonne Université
27 rue Chaligny,
75571 Paris cedex 12